Drug interactions
Fluconazole + Glipizide
Severity: Major
Fluconazole and Glipizide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole increases glipizide exposure, which can lead to enhanced and prolonged hypoglycemia. Cases of symptomatic hypoglycemia have been reported with azole antifungals and sulfonylureas.
What this interaction means in plain words
Fluconazole and Glipizide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Glipizide belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP2C9-mediated glipizide metabolism.
What to do
Monitor blood glucose frequently and reduce the glipizide dose as needed. Educate the patient on hypoglycemia recognition.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Glipizide
Frequently asked questions
Can I take Fluconazole with Glipizide?
MediHelp rates the interaction as major. Fluconazole and Glipizide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole increases glipizide exposure, which can lead to enhanced and prolonged hypoglycemia. Cases of symptomatic hypoglycemia have been reported with azole antifungals and sulfonylureas.
How serious is the interaction between Fluconazole and Glipizide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and reduce the glipizide dose as needed. Educate the patient on hypoglycemia recognition.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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