Drug interactions
Disopyramide + Glipizide
Severity: Major
Disopyramide and Glipizide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia, sometimes severe, and may add to the effect of sulfonylureas. Elderly patients and those with renal impairment are at greater risk.
What this interaction means in plain words
Disopyramide and Glipizide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
Disopyramide stimulates insulin secretion via pancreatic potassium channel effects, adding to sulfonylurea action.
What to do
Monitor blood glucose closely and reduce the glipizide dose if needed. Consider an alternative antiarrhythmic if recurrent hypoglycemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glipizide
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Glipizide?
MediHelp rates the interaction as major. Disopyramide and Glipizide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide can cause hypoglycemia, sometimes severe, and may add to the effect of sulfonylureas. Elderly patients and those with renal impairment are at greater risk.
How serious is the interaction between Disopyramide and Glipizide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the glipizide dose if needed. Consider an alternative antiarrhythmic if recurrent hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glipizide page.
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