Drug interactions
Acetylsalicylic acid + Hydrochlorothiazide
Severity: Minor
Acetylsalicylic acid and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose aspirin may reduce the diuretic and antihypertensive effect of hydrochlorothiazide and can worsen renal function in volume-depleted patients. Hydrochlorothiazide may also raise salicylate effects slightly. Low-dose aspirin has minimal impact.
What this interaction means in plain words
Acetylsalicylic acid and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Prostaglandin inhibition reduces renal blood flow and sodium excretion, blunting thiazide response.
What to do
Monitor blood pressure and renal function if regular analgesic-dose aspirin is used. Ensure adequate hydration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Acetylsalicylic acid with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose aspirin may reduce the diuretic and antihypertensive effect of hydrochlorothiazide and can worsen renal function in volume-depleted patients. Hydrochlorothiazide may also raise salicylate effects slightly. Low-dose aspirin has minimal impact.
How serious is the interaction between Acetylsalicylic acid and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if regular analgesic-dose aspirin is used. Ensure adequate hydration.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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