Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Hydrochlorothiazide
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains hydrochlorothiazide, so adding it separately duplicates the thiazide. This increases the risk of hypotension, volume depletion, hypokalemia, hyponatremia, hyperuricemia and renal impairment.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Therapeutic duplication of thiazide diuretic leads to additive natriuresis and electrolyte loss.
What to do
Avoid taking separate hydrochlorothiazide with this combination and remove the duplicate. If it has been used, check electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Hydrochlorothiazide?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination product already contains hydrochlorothiazide, so adding it separately duplicates the thiazide. This increases the risk of hypotension, volume depletion, hypokalemia, hyponatremia, hyperuricemia and renal impairment.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking separate hydrochlorothiazide with this combination and remove the duplicate. If it has been used, check electrolytes, renal function and blood pressure.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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