Drug interactions
dofetilide + hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ dofetilide levels & hypokalemia → torsades risk.
Mechanism of action
OCT2/MATE inhibition + K⁺ loss.
Clinical management
Contraindicated; use non-thiazide diuretic if needed.
Drug reference
References
Frequently asked questions
Can I take dofetilide with hydrochlorothiazide?
The interaction is rated: Contraindicated. ↑ dofetilide levels & hypokalemia → torsades risk.
How serious is the interaction between dofetilide and hydrochlorothiazide?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between dofetilide and hydrochlorothiazide managed?
Contraindicated; use non-thiazide diuretic if needed.
Why do dofetilide and hydrochlorothiazide interact?
OCT2/MATE inhibition + K⁺ loss.
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