Drug interactions
Amiodarone + Hydrochlorothiazide
Severity: Major
Amiodarone and Hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-induced hypokalaemia and hypomagnesaemia can increase the risk of QT prolongation and torsades de pointes with amiodarone. This is the clinically important concern in this pair.
What this interaction means in plain words
Amiodarone and Hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Diuretic-induced electrolyte depletion adds to amiodarone's QT-prolonging effect.
What to do
Check potassium and magnesium before and regularly during therapy and correct deficits. Monitor the ECG for QT prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Hydrochlorothiazide?
MediHelp rates the interaction as major. Amiodarone and Hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thiazide-induced hypokalaemia and hypomagnesaemia can increase the risk of QT prolongation and torsades de pointes with amiodarone. This is the clinically important concern in this pair.
How serious is the interaction between Amiodarone and Hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and regularly during therapy and correct deficits. Monitor the ECG for QT prolongation.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Hydrochlorothiazide page.
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