Drug interactions
Acetylsalicylic acid + Methylprednisolone
Severity: Moderate
Acetylsalicylic acid and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and aspirin use increases the risk of peptic ulceration and gastrointestinal bleeding. Corticosteroids may also lower serum salicylate levels, which can rise again when the steroid is stopped.
What this interaction means in plain words
Acetylsalicylic acid and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Methylprednisolone belongs to Endocrine.
Why it happens
Additive mucosal injury from reduced gastroprotective prostaglandins and corticosteroid effects, plus steroid-induced increase in salicylate clearance.
What to do
Consider a proton pump inhibitor for gastroprotection in at-risk patients and watch for GI bleeding. Monitor salicylate effect if high-dose aspirin is used and steroid dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Methylprednisolone?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroid and aspirin use increases the risk of peptic ulceration and gastrointestinal bleeding. Corticosteroids may also lower serum salicylate levels, which can rise again when the steroid is stopped.
How serious is the interaction between Acetylsalicylic acid and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor for gastroprotection in at-risk patients and watch for GI bleeding. Monitor salicylate effect if high-dose aspirin is used and steroid dose changes.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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