Drug interactions
Measles mumps and rubella vaccine live + Methylprednisolone
Severity: Contraindicated
Measles mumps and rubella vaccine live and Methylprednisolone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MMR contains live attenuated viruses, which may replicate excessively in patients on immunosuppressive methylprednisolone doses. The vaccine response may also be reduced.
What this interaction means in plain words
Measles mumps and rubella vaccine live and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Corticosteroid-induced immunosuppression impairs clearance of live attenuated viruses.
What to do
Avoid MMR during immunosuppressive steroid therapy and defer until after a washout period per local guidance. Low-dose, short-course or topical steroids generally do not preclude vaccination.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
- Methylprednisolone + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine live with Methylprednisolone?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMR contains live attenuated viruses, which may replicate excessively in patients on immunosuppressive methylprednisolone doses. The vaccine response may also be reduced.
How serious is the interaction between Measles mumps and rubella vaccine live and Methylprednisolone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid MMR during immunosuppressive steroid therapy and defer until after a washout period per local guidance. Low-dose, short-course or topical steroids generally do not preclude vaccination.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps rubella and varicella vaccine live, Measles vaccine. The full list is on the Methylprednisolone page.
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