Drug interactions
Measles mumps rubella and varicella vaccine live + Methylprednisolone
Severity: Contraindicated
Measles mumps rubella and varicella vaccine live and Methylprednisolone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MMRV contains live attenuated viruses, including varicella, which can disseminate in patients receiving immunosuppressive methylprednisolone. The immune response may also be diminished.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Corticosteroid-induced suppression of cell-mediated immunity permits uncontrolled replication of live vaccine viruses.
What to do
Do not administer during immunosuppressive steroid doses; postpone until steroids have been stopped for the recommended interval. Separate MMR and varicella vaccines are not safer, so use the same deferral.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
- Methylprednisolone + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Methylprednisolone?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMRV contains live attenuated viruses, including varicella, which can disseminate in patients receiving immunosuppressive methylprednisolone. The immune response may also be diminished.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Methylprednisolone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer during immunosuppressive steroid doses; postpone until steroids have been stopped for the recommended interval. Separate MMR and varicella vaccines are not safer, so use the same deferral.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles vaccine. The full list is on the Methylprednisolone page.
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