Drug interactions
Measles vaccine + Methylprednisolone
Severity: Contraindicated
Measles vaccine and Methylprednisolone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Measles vaccine is live attenuated, and immunosuppressive doses of methylprednisolone may cause vaccine-virus replication and disease while also impairing the response. This is a recognized precaution in vaccine labeling.
What this interaction means in plain words
Measles vaccine and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Corticosteroid-induced suppression of cellular immunity reduces control of live attenuated virus.
What to do
Do not give live measles vaccine during immunosuppressive steroid doses. Defer until the steroid has been stopped for the interval in local guidance, usually at least one month for high-dose therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Measles vaccine and Methylprednisolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
- Methylprednisolone + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Measles vaccine with Methylprednisolone?
MediHelp rates the interaction as contraindicated. Measles vaccine and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Measles vaccine is live attenuated, and immunosuppressive doses of methylprednisolone may cause vaccine-virus replication and disease while also impairing the response. This is a recognized precaution in vaccine labeling.
How serious is the interaction between Measles vaccine and Methylprednisolone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live measles vaccine during immunosuppressive steroid doses. Defer until the steroid has been stopped for the interval in local guidance, usually at least one month for high-dose therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
