Drug interactions
Acetylsalicylic acid + Nitazoxanide
Severity: Minor
Acetylsalicylic acid and Nitazoxanide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitazoxanide's active metabolite tizoxanide is highly protein bound, so displacement from albumin by other highly bound drugs such as aspirin is theoretically possible. No clinically important effect has been shown.
What this interaction means in plain words
Acetylsalicylic acid and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Nitazoxanide belongs to Anti Bacterial.
Why it happens
Theoretical competition for plasma protein binding sites.
What to do
No specific action is required; monitor for unusual effects if high-dose aspirin is used with nitazoxanide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Acetylsalicylic acid with Nitazoxanide?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitazoxanide's active metabolite tizoxanide is highly protein bound, so displacement from albumin by other highly bound drugs such as aspirin is theoretically possible. No clinically important effect has been shown.
How serious is the interaction between Acetylsalicylic acid and Nitazoxanide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor for unusual effects if high-dose aspirin is used with nitazoxanide.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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