Drug interactions
Nitazoxanide + Vadadustat
Severity: Moderate
Nitazoxanide and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhibitors of OAT1 and OAT3 can raise vadadustat exposure. Higher exposure may cause an excessive or overly rapid rise in hemoglobin and more adverse effects, including thromboembolic events.
What this interaction means in plain words
Nitazoxanide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nitazoxanide belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of renal OAT1/OAT3 transporters reduces vadadustat elimination, raising its AUC.
What to do
Monitor hemoglobin closely after nitazoxanide is started and reduce the vadadustat dose if the response is too large or too rapid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitazoxanide
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Nitazoxanide with Vadadustat?
MediHelp rates the interaction as moderate. Nitazoxanide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhibitors of OAT1 and OAT3 can raise vadadustat exposure. Higher exposure may cause an excessive or overly rapid rise in hemoglobin and more adverse effects, including thromboembolic events.
How serious is the interaction between Nitazoxanide and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely after nitazoxanide is started and reduce the vadadustat dose if the response is too large or too rapid.
What other medicines interact with Nitazoxanide?
MediHelp also lists interactions of Nitazoxanide with, for example, Valproic acid, Acetylsalicylic acid, Aspirin. The full list is on the Nitazoxanide page.
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