Drug interactions
Atenolol-chlorthalidone + Nitazoxanide
Severity: Minor
Atenolol-chlorthalidone and Nitazoxanide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitazoxanide's active metabolite tizoxanide is highly protein bound, so displacement of other highly bound drugs is theoretically possible. Chlorthalidone is bound mainly to red blood cells and the clinical relevance of this interaction is unestablished.
What this interaction means in plain words
Atenolol-chlorthalidone and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atenolol-chlorthalidone belongs to Cardiovascular; Nitazoxanide belongs to Anti Bacterial.
Why it happens
Theoretical plasma protein-binding competition; not clinically established.
What to do
No routine action is needed. Be aware of the theoretical interaction during a short nitazoxanide course and monitor blood pressure and electrolytes if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Atenolol-chlorthalidone with Nitazoxanide?
MediHelp rates the interaction as minor. Atenolol-chlorthalidone and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitazoxanide's active metabolite tizoxanide is highly protein bound, so displacement of other highly bound drugs is theoretically possible. Chlorthalidone is bound mainly to red blood cells and the clinical relevance of this interaction is unestablished.
How serious is the interaction between Atenolol-chlorthalidone and Nitazoxanide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Be aware of the theoretical interaction during a short nitazoxanide course and monitor blood pressure and electrolytes if symptoms develop.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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