Drug interactions
Nitazoxanide + Valproic acid
Severity: Moderate
Nitazoxanide and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitazoxanide's active metabolite tizoxanide is highly protein bound and could theoretically displace valproic acid, which is also highly bound. Clinical significance is uncertain and unbound valproate changes are usually transient.
What this interaction means in plain words
Nitazoxanide and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nitazoxanide belongs to Anti Bacterial; Valproic acid belongs to Central Nervous System.
Why it happens
Competition for plasma protein binding sites between tizoxanide and valproic acid may raise unbound concentrations.
What to do
Monitor for valproate adverse effects such as sedation or tremor during the short nitazoxanide course. Consider checking free valproate levels if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Nitazoxanide with Valproic acid?
MediHelp rates the interaction as moderate. Nitazoxanide and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitazoxanide's active metabolite tizoxanide is highly protein bound and could theoretically displace valproic acid, which is also highly bound. Clinical significance is uncertain and unbound valproate changes are usually transient.
How serious is the interaction between Nitazoxanide and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for valproate adverse effects such as sedation or tremor during the short nitazoxanide course. Consider checking free valproate levels if symptoms occur.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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