Drug interactions
Azilsartan-chlorthalidone + Nitazoxanide
Severity: Minor
Azilsartan-chlorthalidone and Nitazoxanide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitazoxanide's active metabolite tizoxanide is highly protein bound and could theoretically displace other highly bound drugs. Chlorthalidone is moderately bound, and no clinically meaningful interaction has been established in practice.
What this interaction means in plain words
Azilsartan-chlorthalidone and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Nitazoxanide belongs to Anti Bacterial.
Why it happens
Theoretical competition for plasma protein binding sites; clinical significance is not established.
What to do
No routine adjustment is needed; monitor blood pressure and electrolytes as usual during the short nitazoxanide course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan-chlorthalidone and Nitazoxanide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Azilsartan-chlorthalidone
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Nitazoxanide?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitazoxanide's active metabolite tizoxanide is highly protein bound and could theoretically displace other highly bound drugs. Chlorthalidone is moderately bound, and no clinically meaningful interaction has been established in practice.
How serious is the interaction between Azilsartan-chlorthalidone and Nitazoxanide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and electrolytes as usual during the short nitazoxanide course.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
