Drug interactions
Acetylsalicylic acid + Trazodone
Severity: Moderate
Acetylsalicylic acid and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has weak serotonergic activity that can impair platelet function, and with aspirin this raises the risk of bleeding, particularly from the upper gastrointestinal tract. The risk is greater in older patients and those with prior ulcers.
What this interaction means in plain words
Acetylsalicylic acid and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Impaired platelet serotonin uptake combined with aspirin's COX-1 inhibition of platelet aggregation gives additive bleeding risk.
What to do
Monitor for signs of GI bleeding and bruising; consider a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Trazodone?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has weak serotonergic activity that can impair platelet function, and with aspirin this raises the risk of bleeding, particularly from the upper gastrointestinal tract. The risk is greater in older patients and those with prior ulcers.
How serious is the interaction between Acetylsalicylic acid and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and bruising; consider a proton pump inhibitor in high-risk patients.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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