Drug interactions
Ibutilide + Trazodone
Severity: Contraindicated
Ibutilide and Trazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide markedly prolongs the QT interval and causes torsades de pointes, and trazodone adds to this effect. The combination raises the risk of sudden arrhythmic death.
What this interaction means in plain words
Ibutilide and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through repolarization delay.
What to do
Avoid the combination. If ibutilide cardioversion is needed, hold trazodone and monitor ECG with electrolytes corrected.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
- Pimozide + Trazodone Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Trazodone?
MediHelp rates the interaction as contraindicated. Ibutilide and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide markedly prolongs the QT interval and causes torsades de pointes, and trazodone adds to this effect. The combination raises the risk of sudden arrhythmic death.
How serious is the interaction between Ibutilide and Trazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If ibutilide cardioversion is needed, hold trazodone and monitor ECG with electrolytes corrected.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Isocarboxazid, Levoketoconazole. The full list is on the Trazodone page.
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