Drug interactions
Arsenic trioxide + Trazodone
Severity: Contraindicated
Arsenic trioxide and Trazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and arsenic trioxide carries a well-known risk of torsades de pointes. Together the risk of life-threatening ventricular arrhythmia is increased.
What this interaction means in plain words
Arsenic trioxide and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Avoid the combination and choose a non-QT-prolonging alternative to trazodone. If unavoidable, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trazodone
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
- Pimozide + Trazodone Contraindicated
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Trazodone?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and arsenic trioxide carries a well-known risk of torsades de pointes. Together the risk of life-threatening ventricular arrhythmia is increased.
How serious is the interaction between Arsenic trioxide and Trazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging alternative to trazodone. If unavoidable, monitor ECG and correct potassium and magnesium.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Ibutilide, Isocarboxazid, Levoketoconazole. The full list is on the Trazodone page.
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