Drug reference
trazodone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Atypical Antidepressant)
Mechanism of action
Antidepressant structurally unrelated to SSRIs, tricyclics, tetracyclics or MAOIs, but also inhibits neuronal uptake of serotonin (but not NE); it is a histamine and alpha1-adrenergic receptor antagonist; causes adrenoceptor subsensitivity
Common side effects
- Dry mouth
- Dizziness
- Drowsiness
- Headache
- Blurred vision
- Fatigue
- Nausea
Known interactions (2)
- isocarboxazid + trazodone Contraindicated
- indapamide + trazodone Moderate
Related conditions
Frequently asked questions
What drug class is trazodone?
trazodone belongs to: Central Nervous System.
How does trazodone work?
Antidepressant structurally unrelated to SSRIs, tricyclics, tetracyclics or MAOIs, but also inhibits neuronal uptake of serotonin (but not NE); it is a histamine and alpha1-adrenergic receptor antagonist; causes adrenoceptor subsensitivity
What are the common side effects of trazodone?
Dry mouth, Dizziness, Drowsiness, Headache, Blurred vision, Fatigue, Nausea
Which drugs interact with trazodone?
isocarboxazid, indapamide
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