Drug interactions
Acetylsalicylic acid + Vortioxetine
Severity: Moderate
Acetylsalicylic acid and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine inhibits serotonin reuptake and may modestly impair platelet function, so combining it with aspirin can increase bleeding risk. The absolute risk is small with low-dose aspirin.
What this interaction means in plain words
Acetylsalicylic acid and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake adds to aspirin's inhibition of platelet aggregation.
What to do
Monitor for bruising and GI bleeding, particularly in older patients or those with prior ulcers; consider gastroprotection if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Vortioxetine?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine inhibits serotonin reuptake and may modestly impair platelet function, so combining it with aspirin can increase bleeding risk. The absolute risk is small with low-dose aspirin.
How serious is the interaction between Acetylsalicylic acid and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising and GI bleeding, particularly in older patients or those with prior ulcers; consider gastroprotection if risk is high.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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