Drug interactions
Selegiline transdermal + Vortioxetine
Severity: Contraindicated
Selegiline transdermal and Vortioxetine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an irreversible MAO inhibitor, and transdermal delivery gives antidepressant-level MAO inhibition. With vortioxetine this can cause serotonin syndrome and hypertensive reactions.
What this interaction means in plain words
Selegiline transdermal and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Irreversible MAO inhibition combined with vortioxetine serotonin reuptake inhibition causes excessive serotonergic activity.
What to do
Do not co-administer. Allow at least 14 days after stopping selegiline before starting vortioxetine, and at least 21 days after stopping vortioxetine before starting selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline + Vortioxetine Contraindicated
Frequently asked questions
Can I take Selegiline transdermal with Vortioxetine?
MediHelp rates the interaction as contraindicated. Selegiline transdermal and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an irreversible MAO inhibitor, and transdermal delivery gives antidepressant-level MAO inhibition. With vortioxetine this can cause serotonin syndrome and hypertensive reactions.
How serious is the interaction between Selegiline transdermal and Vortioxetine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days after stopping selegiline before starting vortioxetine, and at least 21 days after stopping vortioxetine before starting selegiline.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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