Drug interactions
Rasagiline + Vortioxetine
Severity: Contraindicated
Rasagiline and Vortioxetine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is an MAO-B inhibitor, and combining it with vortioxetine carries a risk of serotonin syndrome. The vortioxetine label contraindicates MAO inhibitors, and rasagiline labeling advises against antidepressants.
What this interaction means in plain words
Rasagiline and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rasagiline belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
MAO inhibition plus serotonin reuptake inhibition leads to excess serotonergic activity.
What to do
Avoid concurrent use. Allow at least 14 days after stopping rasagiline before starting vortioxetine, and at least 14 days after stopping vortioxetine before starting rasagiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
- Selegiline + Vortioxetine Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Vortioxetine?
MediHelp rates the interaction as contraindicated. Rasagiline and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline is an MAO-B inhibitor, and combining it with vortioxetine carries a risk of serotonin syndrome. The vortioxetine label contraindicates MAO inhibitors, and rasagiline labeling advises against antidepressants.
How serious is the interaction between Rasagiline and Vortioxetine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Allow at least 14 days after stopping rasagiline before starting vortioxetine, and at least 14 days after stopping vortioxetine before starting rasagiline.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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