Drug interactions
Linezolid + Vortioxetine
Severity: Contraindicated
Linezolid and Vortioxetine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid inhibits MAO and vortioxetine increases serotonergic transmission, so the combination can cause serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability. Vortioxetine labeling contraindicates use with MAO inhibitors including linezolid.
What this interaction means in plain words
Linezolid and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Linezolid belongs to Anti Bacterial; Vortioxetine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with serotonin reuptake inhibition leads to excess serotonergic activity.
What to do
Avoid; if linezolid is needed urgently, stop vortioxetine and monitor for serotonin syndrome, resuming vortioxetine about 24 hours after the last linezolid dose per labeling.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
- Selegiline + Vortioxetine Contraindicated
Frequently asked questions
Can I take Linezolid with Vortioxetine?
MediHelp rates the interaction as contraindicated. Linezolid and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid inhibits MAO and vortioxetine increases serotonergic transmission, so the combination can cause serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability. Vortioxetine labeling contraindicates use with MAO inhibitors including linezolid.
How serious is the interaction between Linezolid and Vortioxetine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; if linezolid is needed urgently, stop vortioxetine and monitor for serotonin syndrome, resuming vortioxetine about 24 hours after the last linezolid dose per labeling.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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