Drug interactions
Phenelzine + Vortioxetine
Severity: Contraindicated
Phenelzine and Vortioxetine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine with phenelzine may cause serotonin syndrome, which can be life-threatening. Vortioxetine labeling contraindicates use with MAO inhibitors.
What this interaction means in plain words
Phenelzine and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Vortioxetine's serotonin transporter inhibition combined with irreversible MAO inhibition increases synaptic serotonin.
What to do
Do not combine. Wait at least 14 days after stopping phenelzine before starting vortioxetine, and at least 21 days after stopping vortioxetine before starting phenelzine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
- Selegiline + Vortioxetine Contraindicated
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Vortioxetine?
MediHelp rates the interaction as contraindicated. Phenelzine and Vortioxetine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vortioxetine with phenelzine may cause serotonin syndrome, which can be life-threatening. Vortioxetine labeling contraindicates use with MAO inhibitors.
How serious is the interaction between Phenelzine and Vortioxetine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Wait at least 14 days after stopping phenelzine before starting vortioxetine, and at least 21 days after stopping vortioxetine before starting phenelzine.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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