Drug interactions
Aspirin / citric acid / sodium bicarbonate + Clomipramine
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This effervescent preparation contains a full analgesic dose of aspirin, which inhibits platelets. With clomipramine, which also impairs platelet serotonin uptake, the risk of gastrointestinal and other bleeding is increased.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Serotonin reuptake inhibition reduces platelet function, adding to aspirin's COX-1 inhibition.
What to do
Limit the duration of aspirin use and consider gastroprotection in at-risk patients. Advise patients to report black stools or unusual bruising.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin / citric acid / sodium bicarbonate and Clomipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Clomipramine?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This effervescent preparation contains a full analgesic dose of aspirin, which inhibits platelets. With clomipramine, which also impairs platelet serotonin uptake, the risk of gastrointestinal and other bleeding is increased.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of aspirin use and consider gastroprotection in at-risk patients. Advise patients to report black stools or unusual bruising.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
