Drug interactions
Aspirin / citric acid / sodium bicarbonate + Dalteparin
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product inhibits platelet aggregation and can cause gastrointestinal injury, which adds to the anticoagulant effect of dalteparin. Analgesic-dose aspirin particularly raises bleeding risk.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: irreversible COX-1 platelet inhibition plus antithrombin-mediated factor Xa inhibition.
What to do
Avoid analgesic-dose aspirin unless clearly needed; if used, monitor for bleeding and hemoglobin. Prefer paracetamol for pain where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin / citric acid / sodium bicarbonate and Dalteparin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Dalteparin?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product inhibits platelet aggregation and can cause gastrointestinal injury, which adds to the anticoagulant effect of dalteparin. Analgesic-dose aspirin particularly raises bleeding risk.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid analgesic-dose aspirin unless clearly needed; if used, monitor for bleeding and hemoglobin. Prefer paracetamol for pain where suitable.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
