Drug interactions
Aspirin / citric acid / sodium bicarbonate + Dicloxacillin
Severity: Minor
Aspirin / citric acid / sodium bicarbonate and Dicloxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin component can compete with dicloxacillin for protein binding and renal secretion, potentially raising free penicillin levels. The effect is usually small.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate competes for albumin binding and renal tubular secretion of dicloxacillin.
What to do
No routine adjustment is needed; monitor for dicloxacillin adverse effects in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Dicloxacillin?
MediHelp rates the interaction as minor. Aspirin / citric acid / sodium bicarbonate and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The aspirin component can compete with dicloxacillin for protein binding and renal secretion, potentially raising free penicillin levels. The effect is usually small.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Dicloxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for dicloxacillin adverse effects in renal impairment.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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