Drug interactions
Aspirin / citric acid / sodium bicarbonate + Eplerenone
Severity: Minor
Aspirin / citric acid / sodium bicarbonate and Eplerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The effervescent analgesic dose of aspirin may blunt the antihypertensive effect of eplerenone and can reduce renal function. The sodium bicarbonate content adds a sodium load that may also oppose blood pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of renal prostaglandin synthesis by aspirin, plus an added sodium load.
What to do
Monitor blood pressure, renal function and potassium if used regularly. Prefer alternative analgesics for long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Eplerenone?
MediHelp rates the interaction as minor. Aspirin / citric acid / sodium bicarbonate and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The effervescent analgesic dose of aspirin may blunt the antihypertensive effect of eplerenone and can reduce renal function. The sodium bicarbonate content adds a sodium load that may also oppose blood pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Eplerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium if used regularly. Prefer alternative analgesics for long-term use.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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