Drug interactions
Aspirin / citric acid / sodium bicarbonate + Ethinyl estradiol-drospirenone
Severity: Minor
Aspirin / citric acid / sodium bicarbonate and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can raise serum potassium, and the aspirin in this effervescent analgesic may add a small effect at analgesic doses. Clinically relevant hyperkalemia is unlikely in patients with normal renal function.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive potassium retention from drospirenone aldosterone antagonism and aspirin inhibition of renal prostaglandins.
What to do
No routine action is needed for occasional use. Check serum potassium if the product is taken frequently or renal function is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Aspirin / citric acid / sodium bicarbonate and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone can raise serum potassium, and the aspirin in this effervescent analgesic may add a small effect at analgesic doses. Clinically relevant hyperkalemia is unlikely in patients with normal renal function.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for occasional use. Check serum potassium if the product is taken frequently or renal function is reduced.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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