Drug interactions
Aspirin / citric acid / sodium bicarbonate + Hydrochlorothiazide-lisinopril
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This effervescent analgesic contains analgesic-dose aspirin, which can reduce the antihypertensive effect of lisinopril and hydrochlorothiazide and impair renal function in volume-depleted patients. The sodium load from the preparation may also raise blood pressure.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandin synthesis causing sodium and fluid retention, and the sodium bicarbonate adds a sodium load, opposing antihypertensive therapy.
What to do
Limit use to short courses, and monitor blood pressure, renal function and potassium if used regularly. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This effervescent analgesic contains analgesic-dose aspirin, which can reduce the antihypertensive effect of lisinopril and hydrochlorothiazide and impair renal function in volume-depleted patients. The sodium load from the preparation may also raise blood pressure.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses, and monitor blood pressure, renal function and potassium if used regularly. Consider paracetamol as an alternative.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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