Drug interactions
Benazepril + Hydrochlorothiazide-lisinopril
Severity: Major
Benazepril and Hydrochlorothiazide-lisinopril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benazepril duplicates the ACE inhibitor lisinopril, giving no added benefit and increasing the risk of hypotension, hyperkalemia and acute kidney injury. Dual ACE inhibitor therapy should not be used.
What this interaction means in plain words
Benazepril and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benazepril belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Therapeutic duplication causing excessive ACE inhibition and reduced angiotensin II and aldosterone.
What to do
Avoid combining two ACE inhibitors and discontinue one. Monitor blood pressure, creatinine and potassium after the change.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
- Candesartan + Hydrochlorothiazide-lisinopril Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Benazepril and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benazepril duplicates the ACE inhibitor lisinopril, giving no added benefit and increasing the risk of hypotension, hyperkalemia and acute kidney injury. Dual ACE inhibitor therapy should not be used.
How serious is the interaction between Benazepril and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ACE inhibitors and discontinue one. Monitor blood pressure, creatinine and potassium after the change.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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