Drug interactions
Aspirin / citric acid / sodium bicarbonate + Losartan
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product can reduce the blood pressure effect of losartan and impair renal function when taken at analgesic doses regularly. The risk is higher in elderly or volume-depleted patients. The sodium load may also modestly counteract antihypertensive therapy.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandin synthesis, reducing renal perfusion and opposing ARB effects.
What to do
Avoid regular use where possible; if needed, monitor blood pressure, creatinine and potassium. Consider paracetamol for occasional pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Losartan?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product can reduce the blood pressure effect of losartan and impair renal function when taken at analgesic doses regularly. The risk is higher in elderly or volume-depleted patients. The sodium load may also modestly counteract antihypertensive therapy.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where possible; if needed, monitor blood pressure, creatinine and potassium. Consider paracetamol for occasional pain.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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