Drug interactions
Aspirin / citric acid / sodium bicarbonate + Mycophenolate mofetil
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product is usually given at analgesic doses, and salicylate can compete with mycophenolic acid glucuronide for renal secretion and albumin binding. The antacid components may also reduce mycophenolate absorption.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate competition for renal secretion and protein binding, plus reduced mycophenolate absorption from antacid effects.
What to do
Separate dosing from the effervescent product by at least 2 hours and monitor for GI toxicity and cytopenias. Prefer paracetamol for routine analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product is usually given at analgesic doses, and salicylate can compete with mycophenolic acid glucuronide for renal secretion and albumin binding. The antacid components may also reduce mycophenolate absorption.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing from the effervescent product by at least 2 hours and monitor for GI toxicity and cytopenias. Prefer paracetamol for routine analgesia.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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