Drug interactions
Aspirin rectal + Dalteparin
Severity: Major
Aspirin rectal and Dalteparin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin irreversibly inhibits platelet function, and rectal use still produces systemic antiplatelet effects, which increases bleeding risk with dalteparin. The risk is mainly gastrointestinal or other hemorrhage.
What this interaction means in plain words
Aspirin rectal and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Irreversible platelet COX-1 inhibition adds to dalteparin's anti-Xa anticoagulation.
What to do
Combine only when a clear indication exists, such as acute coronary syndrome, and use the lowest effective aspirin dose. Monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Aspirin rectal with Dalteparin?
MediHelp rates the interaction as major. Aspirin rectal and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aspirin irreversibly inhibits platelet function, and rectal use still produces systemic antiplatelet effects, which increases bleeding risk with dalteparin. The risk is mainly gastrointestinal or other hemorrhage.
How serious is the interaction between Aspirin rectal and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Combine only when a clear indication exists, such as acute coronary syndrome, and use the lowest effective aspirin dose. Monitor for bleeding and hemoglobin.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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