Drug interactions
Aspirin rectal + Dicloxacillin
Severity: Minor
Aspirin rectal and Dicloxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic salicylate from rectal aspirin can compete with dicloxacillin for protein binding and renal secretion, possibly raising free penicillin levels. The effect is usually minor.
What this interaction means in plain words
Aspirin rectal and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate competes for albumin binding and renal tubular secretion of dicloxacillin.
What to do
No routine adjustment is needed; monitor for dicloxacillin adverse effects in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Aspirin rectal with Dicloxacillin?
MediHelp rates the interaction as minor. Aspirin rectal and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic salicylate from rectal aspirin can compete with dicloxacillin for protein binding and renal secretion, possibly raising free penicillin levels. The effect is usually minor.
How serious is the interaction between Aspirin rectal and Dicloxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for dicloxacillin adverse effects in renal impairment.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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