Drug interactions
Aspirin rectal + Eplerenone
Severity: Minor
Aspirin rectal and Eplerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin at analgesic or anti-inflammatory doses may reduce the blood pressure lowering effect of eplerenone and impair renal function. Low-dose aspirin is much less likely to matter.
What this interaction means in plain words
Aspirin rectal and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of renal prostaglandin synthesis causing sodium and fluid retention.
What to do
Monitor blood pressure, renal function and potassium if regular higher-dose aspirin is used. No action is needed for occasional or low-dose use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin rectal and Eplerenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Aspirin rectal with Eplerenone?
MediHelp rates the interaction as minor. Aspirin rectal and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aspirin at analgesic or anti-inflammatory doses may reduce the blood pressure lowering effect of eplerenone and impair renal function. Low-dose aspirin is much less likely to matter.
How serious is the interaction between Aspirin rectal and Eplerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium if regular higher-dose aspirin is used. No action is needed for occasional or low-dose use.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
