Drug interactions
Aspirin rectal + Gentamicin
Severity: Moderate
Aspirin rectal and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin at analgesic doses is absorbed systemically and can impair renal prostaglandin-dependent perfusion, potentially adding to gentamicin nephrotoxicity. The risk is greater in dehydrated patients or those with renal impairment.
What this interaction means in plain words
Aspirin rectal and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate inhibition of renal prostaglandin synthesis reduces renal perfusion and may decrease aminoglycoside clearance.
What to do
Monitor serum creatinine and gentamicin concentrations during combined use, and keep the patient well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Aspirin rectal with Gentamicin?
MediHelp rates the interaction as moderate. Aspirin rectal and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin at analgesic doses is absorbed systemically and can impair renal prostaglandin-dependent perfusion, potentially adding to gentamicin nephrotoxicity. The risk is greater in dehydrated patients or those with renal impairment.
How serious is the interaction between Aspirin rectal and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin concentrations during combined use, and keep the patient well hydrated.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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