Drug interactions
Aspirin rectal + Hydrochlorothiazide-lisinopril
Severity: Moderate
Aspirin rectal and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and at analgesic doses can blunt the effects of lisinopril and hydrochlorothiazide and impair renal function in volume-depleted patients. Low antiplatelet doses carry little concern.
What this interaction means in plain words
Aspirin rectal and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium retention and reduced renal perfusion, opposing ACE inhibitor and diuretic effects.
What to do
With regular higher doses, monitor blood pressure, creatinine and potassium and ensure hydration. Low-dose aspirin needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Aspirin rectal with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Aspirin rectal and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and at analgesic doses can blunt the effects of lisinopril and hydrochlorothiazide and impair renal function in volume-depleted patients. Low antiplatelet doses carry little concern.
How serious is the interaction between Aspirin rectal and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With regular higher doses, monitor blood pressure, creatinine and potassium and ensure hydration. Low-dose aspirin needs no change.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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