Drug interactions
Aspirin rectal + Losartan
Severity: Moderate
Aspirin rectal and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed aspirin given rectally can reduce losartan antihypertensive effect and impair renal function at anti-inflammatory doses. Risk is greater in elderly or volume-depleted patients.
What this interaction means in plain words
Aspirin rectal and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandin synthesis, opposing ARB-mediated vasodilation and affecting renal perfusion.
What to do
Monitor blood pressure and renal function if higher aspirin doses are used repeatedly. Low-dose use usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Aspirin rectal with Losartan?
MediHelp rates the interaction as moderate. Aspirin rectal and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed aspirin given rectally can reduce losartan antihypertensive effect and impair renal function at anti-inflammatory doses. Risk is greater in elderly or volume-depleted patients.
How serious is the interaction between Aspirin rectal and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if higher aspirin doses are used repeatedly. Low-dose use usually needs no change.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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