Drug interactions
Aspirin rectal + Metoprolol
Severity: Minor
Aspirin rectal and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic doses of aspirin used regularly may reduce the antihypertensive effect of metoprolol. Occasional or low-dose aspirin is unlikely to matter.
What this interaction means in plain words
Aspirin rectal and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Prostaglandin synthesis inhibition causes sodium and water retention and attenuates vasodilation.
What to do
Monitor blood pressure if high-dose aspirin is used regularly. No action needed for occasional or low-dose use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Aspirin rectal with Metoprolol?
MediHelp rates the interaction as minor. Aspirin rectal and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Analgesic doses of aspirin used regularly may reduce the antihypertensive effect of metoprolol. Occasional or low-dose aspirin is unlikely to matter.
How serious is the interaction between Aspirin rectal and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if high-dose aspirin is used regularly. No action needed for occasional or low-dose use.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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