Drug interactions
Aspirin rectal + Piroxicam
Severity: Major
Aspirin rectal and Piroxicam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically, so combining it with piroxicam increases the risk of gastrointestinal and other bleeding. Piroxicam may also interfere with the antiplatelet effect of aspirin.
What this interaction means in plain words
Aspirin rectal and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive COX inhibition and platelet dysfunction, with competition at the COX-1 site.
What to do
Avoid the combination where possible and use gastroprotection if both are required. Monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Aspirin rectal with Piroxicam?
MediHelp rates the interaction as major. Aspirin rectal and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rectal aspirin is absorbed systemically, so combining it with piroxicam increases the risk of gastrointestinal and other bleeding. Piroxicam may also interfere with the antiplatelet effect of aspirin.
How serious is the interaction between Aspirin rectal and Piroxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use gastroprotection if both are required. Monitor for bleeding.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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