Drug interactions
Astragalus + Sirolimus
Severity: Moderate
Astragalus and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Astragalus has immune-stimulating properties that could oppose the effect of sirolimus, potentially reducing protection against rejection. Clinical data are scarce.
What this interaction means in plain words
Astragalus and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical pharmacodynamic antagonism from immune stimulation by astragalus.
What to do
Advise transplant patients to avoid astragalus products. If used, monitor graft function and sirolimus levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Astragalus with Sirolimus?
MediHelp rates the interaction as moderate. Astragalus and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Astragalus has immune-stimulating properties that could oppose the effect of sirolimus, potentially reducing protection against rejection. Clinical data are scarce.
How serious is the interaction between Astragalus and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise transplant patients to avoid astragalus products. If used, monitor graft function and sirolimus levels.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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