Drug interactions
Atazanavir + Chlorpropamide
Severity: Minor
Atazanavir and Chlorpropamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir has relatively little effect on glucose among protease inhibitors, but hyperglycemia and insulin resistance have been reported with this class and could reduce the effectiveness of chlorpropamide.
What this interaction means in plain words
Atazanavir and Chlorpropamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Chlorpropamide belongs to Endocrine.
Why it happens
Protease inhibitors may induce insulin resistance and impair beta-cell function, opposing sulfonylurea action.
What to do
Monitor blood glucose after atazanavir is started and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atazanavir and Chlorpropamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpropamide
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Chlorpropamide?
MediHelp rates the interaction as minor. Atazanavir and Chlorpropamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir has relatively little effect on glucose among protease inhibitors, but hyperglycemia and insulin resistance have been reported with this class and could reduce the effectiveness of chlorpropamide.
How serious is the interaction between Atazanavir and Chlorpropamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after atazanavir is started and adjust antidiabetic therapy if control worsens.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
