Drug interactions
Atazanavir + Clonazepam
Severity: Moderate
Atazanavir and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, a ritonavir-free or boosted protease inhibitor, inhibits CYP3A4 and can raise clonazepam concentrations. This may cause excess sedation, confusion and respiratory depression.
What this interaction means in plain words
Atazanavir and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Clonazepam belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated clonazepam metabolism.
What to do
Start with a lower clonazepam dose and titrate to effect. Monitor for oversedation and reduce the dose if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Clonazepam?
MediHelp rates the interaction as moderate. Atazanavir and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir, a ritonavir-free or boosted protease inhibitor, inhibits CYP3A4 and can raise clonazepam concentrations. This may cause excess sedation, confusion and respiratory depression.
How serious is the interaction between Atazanavir and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower clonazepam dose and titrate to effect. Monitor for oversedation and reduce the dose if it occurs.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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