Drug interactions
Atazanavir + Cyclosporin
Severity: Major
Atazanavir and Cyclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, a CYP3A4 inhibitor, can raise cyclosporine concentrations, increasing the risk of nephrotoxicity, hypertension and neurotoxicity. The magnitude varies between patients.
What this interaction means in plain words
Atazanavir and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Cyclosporin belongs to Miscellaneous.
Why it happens
Atazanavir inhibits CYP3A4-mediated metabolism of cyclosporine, and possibly P-glycoprotein.
What to do
Monitor cyclosporine trough levels and renal function closely when starting or stopping atazanavir, and reduce the cyclosporine dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Cyclosporin?
MediHelp rates the interaction as major. Atazanavir and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir, a CYP3A4 inhibitor, can raise cyclosporine concentrations, increasing the risk of nephrotoxicity, hypertension and neurotoxicity. The magnitude varies between patients.
How serious is the interaction between Atazanavir and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function closely when starting or stopping atazanavir, and reduce the cyclosporine dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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