Drug interactions
Atazanavir + Desvenlafaxine
Severity: Minor
Atazanavir and Desvenlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4, which is a minor elimination pathway for desvenlafaxine, so exposure may rise modestly. Increased adverse effects such as nausea, blood pressure elevation or dizziness are possible but usually manageable.
What this interaction means in plain words
Atazanavir and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Desvenlafaxine belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by atazanavir reduces the minor oxidative clearance of desvenlafaxine.
What to do
No empirical dose change is usually needed. Monitor tolerability and blood pressure, reducing the desvenlafaxine dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Desvenlafaxine?
MediHelp rates the interaction as minor. Atazanavir and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atazanavir inhibits CYP3A4, which is a minor elimination pathway for desvenlafaxine, so exposure may rise modestly. Increased adverse effects such as nausea, blood pressure elevation or dizziness are possible but usually manageable.
How serious is the interaction between Atazanavir and Desvenlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is usually needed. Monitor tolerability and blood pressure, reducing the desvenlafaxine dose if adverse effects appear.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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