Drug interactions
Atazanavir + Didanosine
Severity: Moderate
Atazanavir and Didanosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir needs an acidic gastric environment and food for optimal absorption, while buffered didanosine formulations raise gastric pH and must be taken fasting. Given together, atazanavir absorption may fall, risking reduced antiviral efficacy.
What this interaction means in plain words
Atazanavir and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Didanosine belongs to Anti Virals.
Why it happens
Buffered didanosine formulations raise gastric pH, reducing atazanavir solubility and absorption; food-timing requirements also conflict.
What to do
Give atazanavir with food at least 2 hours before or 1 hour after didanosine, and monitor HIV viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Didanosine?
MediHelp rates the interaction as moderate. Atazanavir and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir needs an acidic gastric environment and food for optimal absorption, while buffered didanosine formulations raise gastric pH and must be taken fasting. Given together, atazanavir absorption may fall, risking reduced antiviral efficacy.
How serious is the interaction between Atazanavir and Didanosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give atazanavir with food at least 2 hours before or 1 hour after didanosine, and monitor HIV viral load.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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