Drug interactions
Atazanavir + Drospirenone
Severity: Moderate
Atazanavir and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may raise drospirenone exposure, increasing the risk of hyperkalemia, while boosted regimens may also alter ethinylestradiol levels. Contraceptive efficacy can be unpredictable.
What this interaction means in plain words
Atazanavir and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Drospirenone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by atazanavir altering drospirenone metabolism, with potential effects on the paired estrogen.
What to do
Prefer an alternative or non-hormonal contraceptive method. If used together, monitor serum potassium and consider renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Drospirenone?
MediHelp rates the interaction as moderate. Atazanavir and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and may raise drospirenone exposure, increasing the risk of hyperkalemia, while boosted regimens may also alter ethinylestradiol levels. Contraceptive efficacy can be unpredictable.
How serious is the interaction between Atazanavir and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative or non-hormonal contraceptive method. If used together, monitor serum potassium and consider renal function.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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