Drug interactions
Atazanavir + Fludrocortisone
Severity: Moderate
Atazanavir and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may raise fludrocortisone concentrations, strengthening mineralocorticoid effects. This may lead to hypokalemia, hypertension and fluid retention.
What this interaction means in plain words
Atazanavir and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Fludrocortisone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fludrocortisone by atazanavir.
What to do
Monitor blood pressure, edema and serum potassium. Reduce the fludrocortisone dose if excess mineralocorticoid effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Fludrocortisone?
MediHelp rates the interaction as moderate. Atazanavir and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and may raise fludrocortisone concentrations, strengthening mineralocorticoid effects. This may lead to hypokalemia, hypertension and fluid retention.
How serious is the interaction between Atazanavir and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium. Reduce the fludrocortisone dose if excess mineralocorticoid effects appear.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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