Drug interactions
Atazanavir + Gliclazide
Severity: Minor
Atazanavir and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors have been associated with insulin resistance and hyperglycemia, which can reduce the effectiveness of gliclazide. Atazanavir has a relatively weaker metabolic effect than other protease inhibitors, so the impact is often modest.
What this interaction means in plain words
Atazanavir and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atazanavir belongs to Anti Virals; Gliclazide belongs to Endocrine.
Why it happens
Protease inhibitors can induce insulin resistance and impair glucose tolerance, opposing the effect of the sulfonylurea.
What to do
Monitor blood glucose and HbA1c after starting atazanavir and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Gliclazide?
MediHelp rates the interaction as minor. Atazanavir and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Protease inhibitors have been associated with insulin resistance and hyperglycemia, which can reduce the effectiveness of gliclazide. Atazanavir has a relatively weaker metabolic effect than other protease inhibitors, so the impact is often modest.
How serious is the interaction between Atazanavir and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting atazanavir and adjust antidiabetic therapy if control worsens.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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